NMN VS NR

NMN (Nicotinamide Mononucleotide) vs NR (Nicotinamide Riboside)

NMN (Nicotinamide Mononucleotide) and NAD (Nicotinamide Adenine Dinucleotide) are becoming increasingly popular due to their potential role in enhancing cellular energy and supporting overall health. People are curious about these compounds, especially since they have recently been in the news for their life-extending benefits.

Both NMN and NR (Nicotinamide Riboside) are biosynthetic precursors to NAD, a crucial molecule involved in cellular energy production. As NAD levels naturally decline with age, people are looking for ways to replenish these levels, with NMN and NR often cited as potential solutions. But what is the difference between NMN and NR? And which one is preferred?

What are NAD, NMN, and NR?

To fully understand how NMN and NR contribute to our health, it is important to understand what NAD, NMN, and NR actually are.

NAD

NAD, or Nicotinamide Adenine Dinucleotide, is a coenzyme found in every cell of the body and is essential for cellular energy production. It plays a crucial role in supporting the mitochondria, the 'powerhouses' of the cells, which convert glucose and fats into usable energy. As we age, our NAD levels naturally decline, which can lead to reduced energy, fatigue, and even certain age-related conditions.

Nicotinamide Riboside

Nicotinamide Riboside, or NR for short, is a vitamin B3 compound and a precursor to NAD. It helps produce NAD in the body, making it a popular choice for people looking to boost their NAD levels. NR is available as a supplement and is the subject of promising research regarding energy production and aging.

NMN

Nicotinamide Mononucleotide (NMN) is another precursor to NAD and is converted into NAD in the body via an enzymatic reaction. Like NR, NMN has gained significant attention for its potential to boost NAD levels, making it a popular choice among health-conscious individuals.

NMN NR

NMN Preferred Over Nicotinamide Riboside by Leading Experts

The debate over the effectiveness of NMN versus Nicotinamide Riboside has garnered considerable attention from scientists and health experts worldwide. One of the most prominent experts in this field is Dr. David Sinclair, a professor of genetics at Harvard University. Dr. Sinclair is globally renowned for his groundbreaking research into the role of NAD in the aging process and potential ways to slow aging.

In his research, Dr. Sinclair has extensively studied both NR and NMN and how these NAD precursors can affect cellular health and lifespan. Despite the promise of both compounds, he has personally favored NMN. Dr. Sinclair takes NMN daily, believing in its potential to effectively raise NAD levels and thus mitigate the detrimental effects of aging.

Research on NMN and NR

It is important to understand how NMN and NR differ on a molecular level, particularly in how they are absorbed and used by the body. One notable difference between these compounds is their molecular size. NMN is significantly larger than Nicotinamide Riboside, which means it cannot be directly transported across the cell membrane. Due to this larger molecular size, NMN must first be broken down into a smaller, more absorbable form before it can enter the cell. This makes NR somewhat easier to absorb because it is smaller and more stable, able to pass directly through the cell membrane. Once inside the cell, NR can be quickly converted into NAD, thus contributing to cellular energy production.

These differences in molecular size and absorption have led to considerable research into the effectiveness and bioavailability of both NMN and NR. While NR may be more easily absorbed directly, research indicates that NMN, once broken down and inside the cell, is equally capable of raising NAD levels and contributing to cellular energy production.

Key Differences and Factors

While both NMN and NR act as NAD precursors, there are important differences between these two compounds. The most distinguishing difference is that NMN is one step closer to producing NAD compared to NR. Here's how the process works:

  1. NR to NAD Pathway: NR must first be converted into NMN before it can be used to make NAD. This means that NR undergoes the intermediate step of phosphorylation to become NMN, which is then converted into NAD.
  2. NMN to NAD Pathway: NMN, on the other hand, does not need to be converted before it can contribute to the production of NAD. Once inside the cell, NMN is directly converted into NAD, making it more efficient in this process.

NAD is crucial for the function of sirtuins and PARP enzymes, which play important roles in DNA repair and maintaining the epigenome.

Other differences between NR and NMN:

  • NMN is larger than NR.
  • NMN supplements are less widely available than NR supplements.
  • Although both compounds are the subject of scientific research, more research has been conducted on NR.
  • NR supplements are typically available in powder and capsule form, while NMN supplements are usually only available in powder form.
  • NR is more susceptible to degradation by stomach acid, while NMN is considered more stable for oral use.

Comparison of Bioavailability

NR is often considered more absorbable due to its smaller molecular size, making it easier to be taken up by the cell membrane. Once absorbed, NR is converted into NMN, which then contributes to NAD production. NMN, on the other hand, although larger and requiring an extra step to enter the cell, also shows promising bioavailability. New research suggests that the body may have specific transport mechanisms that support the use of NMN, aiding its absorption and conversion to NAD.

Which is Preferred: NMN or NR?

Based on scientific research, NMN appears to have an edge over NR in terms of effectiveness in raising NAD levels. Furthermore, studies suggest that NMN may yield better results for supporting anti-aging mechanisms than NR. This includes improvements in cellular energy production and DNA repair, as well as activating sirtuins associated with longer lifespan.

On a molecular level, NMN also resembles NAD more closely than NR, potentially enhancing efficiency further. This molecular proximity may make NMN more suitable for individuals focused on improving their NAD levels and supporting overall health.

While both compounds are potentially useful for raising NAD, research indicates that NMN may be preferred for those seeking the most effective and direct way to boost NAD.

Ordering NMN from EnduraVita

If you are looking for high-quality NMN, EnduraVita is the right place for you. It is important to ensure that NMN supplements are used at the correct dosage to ensure maximum effectiveness and safety. Check out this blog on NMN dosages to find the recommended dosage for your specific needs. For more information about our full range, visit our product page.

Conclusion

While both NMN and NR are important for raising NAD levels, NMN seems to have a slight advantage. This is mainly due to the molecular similarity to NAD and recent research suggesting that NMN more directly and effectively contributes to NAD production. Although NR offers easier absorption through cell membranes, the potential anti-aging effects and the direct conversion process of NMN to NAD are points in favor of NMN. Therefore, NMN, as recommended by leading experts in the field, including Dr. David Sinclair, is often seen as a more direct and potentially powerful way to support and improve cellular health.

```

Back to blog

Order one of our Premium NMN products now.

  • Highest purity & maximum biological uptake

    We opt only for the highest quality supplements, ensuring maximum absorption by the body. For instance, our NMN boasts a purity level of >99.8%.

  • Independently laboratory tested

    All supplements undergo double testing and verification in a laboratory for quality, including in NL(EU) or USA.

  • High-quality production (GMP)

    Our supplements are produced according to strict requirements for good and safe production, adhering to various ISO standards within this framework.

  • Onderzoek: activatie van SIRT1 door Resveratrol, een grote stap tegen veroudering

    Research: activation of SIRT1 by Resveratrol, a...

    Sirtuins, specifically SIRTs, are essential proteins that influence various cellular processes, such as mitochondrial function and genome integrity. In mammals, seven variants of sirtuins (SIRT1-SIRT7) have been identified so far,...

    Research: activation of SIRT1 by Resveratrol, a...

    Sirtuins, specifically SIRTs, are essential proteins that influence various cellular processes, such as mitochondrial function and genome integrity. In mammals, seven variants of sirtuins (SIRT1-SIRT7) have been identified so far,...

  • NMN voorkomt schade aan luchtwegen door luchtvervuiling

    Research: NMN Protects Lungs Against Damage fro...

    Inhaling of polluted air can lead to a decrease in NAD+ levels, resulting in inflammation and lung damage. Nevertheless, research shows that the use of NMN, a precursor of NAD+,...

    Research: NMN Protects Lungs Against Damage fro...

    Inhaling of polluted air can lead to a decrease in NAD+ levels, resulting in inflammation and lung damage. Nevertheless, research shows that the use of NMN, a precursor of NAD+,...

  • NMN Studie: NMN is veilig en verhoogt NAD+ niveaus in het lichaam

    NMN Study: NMN is safe and increases NAD+ level...

    Recent research (April 2022) demonstrates that the oral administration of nicotinamide mononucleotide is safe and efficiently increases the blood levels of nicotinamide adenine dinucleotide in healthy subjects. Summary of results:...

    NMN Study: NMN is safe and increases NAD+ level...

    Recent research (April 2022) demonstrates that the oral administration of nicotinamide mononucleotide is safe and efficiently increases the blood levels of nicotinamide adenine dinucleotide in healthy subjects. Summary of results:...

1 of 3