Studie: NMN verlaagt bloeddruk, gewicht & cholesterol. NAD-niveaus namen toe.

Study: NMN Reduces Blood Pressure, Weight, & Cholesterol Levels. NAD Levels Increased.

Summary results:

  • Treatment with MIB-626 resulted in a significant increase in blood NAD levels from baseline to day 14 and day 28.

  • Levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, and non-high-density lipoprotein (HDL) cholesterol in serum decreased from baseline in the MIB-626 group.
  • Body weight decreased in participants randomly assigned to the MIB-626 group and increased in those assigned to the placebo group; the difference in weight change between the groups was statistically significant.
  • Diastolic blood pressure decreased from baseline in the MIB-626 group.

Research Summary:

Background: With aging, nicotinamide adenine dinucleotide (NAD) levels decline, and this decline is presumed to contribute to age-related diseases.

Objective: We evaluated the safety and physiological effects of NAD augmentation by administering the precursor, β-nicotinamide mononucleotide (MIB-626, Metro International Biotech, Worcester, MA), in adults at increased risk of age-related conditions.

Methods: In a randomized allocation of 2:1, thirty overweight or obese adults, ≥45 years old, were assigned to take 2 MIB-626 tablets containing 500 mg of microcrystalline β-nicotinamide mononucleotide or a placebo, twice daily for 28 days. Study outcomes included safety; NAD and its metabolome; body weight; liver, muscle, and intra-abdominal fat; insulin sensitivity; blood pressure; lipids; physical performance; and muscle bioenergetics.

Results: There were similar adverse events between groups. MIB-626 treatment resulted in significantly increased circulating concentrations of NAD and its metabolites. Body weight (difference -1.9 [-3.3, -0.5] kg, P = .008); diastolic blood pressure (difference -7.01 [-13.44, -0.59] mmHg, P = .034); total cholesterol (difference -26.89 [-44.34, -9.44] mg/dL, P = .004), low-density lipoprotein (LDL) cholesterol (-18.73 [-31.85, -5.60] mg/dL, P = .007), and non-high-density lipoprotein cholesterol decreased significantly more in the MIB-626 group than in the placebo group. No significant differences were observed between groups regarding changes in muscle strength, muscle fatigue, aerobic capacity, and stair-climbing ability. Insulin sensitivity and hepatic and intra-abdominal fat did not change in either group.

Conclusion: In overweight or obese middle-aged and older adults, MIB-626 administration safely increased circulating NAD levels and resulted in significant reductions in total LDL and non-HDL cholesterol, body weight, and diastolic blood pressure. These findings justify further large-scale investigations into the effectiveness of NAD augmentation in improving cardiometabolic outcomes in older adults.

 

Source: https://pubmed.ncbi.nlm.nih.gov/36740954/




 

Back to blog

Order one of our Premium NMN products now.

  • Highest purity & maximum biological uptake

    We opt only for the highest quality supplements, ensuring maximum absorption by the body. For instance, our NMN boasts a purity level of >99.8%.

  • Independently laboratory tested

    All supplements undergo double testing and verification in a laboratory for quality, including in NL(EU) or USA.

  • High-quality production (GMP)

    Our supplements are produced according to strict requirements for good and safe production, adhering to various ISO standards within this framework.

  • Onderzoek: activatie van SIRT1 door Resveratrol, een grote stap tegen veroudering

    Research: activation of SIRT1 by Resveratrol, a...

    Sirtuins, specifically SIRTs, are essential proteins that influence various cellular processes, such as mitochondrial function and genome integrity. In mammals, seven variants of sirtuins (SIRT1-SIRT7) have been identified so far,...

    Research: activation of SIRT1 by Resveratrol, a...

    Sirtuins, specifically SIRTs, are essential proteins that influence various cellular processes, such as mitochondrial function and genome integrity. In mammals, seven variants of sirtuins (SIRT1-SIRT7) have been identified so far,...

  • NMN voorkomt schade aan luchtwegen door luchtvervuiling

    Research: NMN Protects Lungs Against Damage fro...

    Inhaling of polluted air can lead to a decrease in NAD+ levels, resulting in inflammation and lung damage. Nevertheless, research shows that the use of NMN, a precursor of NAD+,...

    Research: NMN Protects Lungs Against Damage fro...

    Inhaling of polluted air can lead to a decrease in NAD+ levels, resulting in inflammation and lung damage. Nevertheless, research shows that the use of NMN, a precursor of NAD+,...

  • NMN Studie: NMN is veilig en verhoogt NAD+ niveaus in het lichaam

    NMN Study: NMN is safe and increases NAD+ level...

    Recent research (April 2022) demonstrates that the oral administration of nicotinamide mononucleotide is safe and efficiently increases the blood levels of nicotinamide adenine dinucleotide in healthy subjects. Summary of results:...

    NMN Study: NMN is safe and increases NAD+ level...

    Recent research (April 2022) demonstrates that the oral administration of nicotinamide mononucleotide is safe and efficiently increases the blood levels of nicotinamide adenine dinucleotide in healthy subjects. Summary of results:...

1 of 3