NMN veiligheidsstudie: Effect van NMN op klinische parameters

NMN safety study: Effect of NMN on clinical parameters

In 2020, a study was conducted to investigate the safety of NMN by examining various clinical parameters while administering NMN to the participants.

Summary of Results:

  • Administering a single dose of NMN orally did not cause significant clinical symptoms or changes in heart rate, blood pressure, oxygen saturation, and body temperature.
  • Laboratory analysis results showed no significant changes, except for an increase in serum bilirubin levels and a decrease in creatinine, chloride, and blood glucose levels within normal ranges, regardless of the NMN dose.
  • Results of ophthalmologic examination and sleep quality score showed no differences before and after the intervention.
  • Concentrations of N-methyl-2-pyridone-5-carboxamide and N-methyl-4-pyridone-5-carboxamide in plasma significantly increased depending on the NMN administration dose.
  • Single oral administration of NMN was safe and effectively metabolized in healthy men without causing significant adverse effects. This indicates that oral administration of NMN is feasible and may be a potential therapeutic strategy to reduce age-related conditions in humans.

Extended Summary of the Research by the Investigators:

Recent studies have shown that reduced levels of the cellular coenzyme nicotinamide adenine dinucleotide (NAD+) cause age-related conditions. Therapeutic approaches that increase NAD+ levels can prevent these conditions in animal models. Nicotinamide mononucleotide (NMN) has been shown to be effective in combating age-related issues. However, the safety of NMN for human use is not yet clear.

For this reason, we conducted a clinical study to investigate the safety of single-dose NMN administration in 10 healthy men. The study involved a single-arm, non-randomized intervention, where participants were administered a single oral dose of 100, 250, or 500 mg NMN. For 5 hours after each intervention, we examined clinical findings, parameters, and the pharmacokinetics of NMN metabolites. Additionally, we also conducted ophthalmologic examination and sleep quality evaluation before and after NMN administration.

Our results showed that single oral administration of NMN did not cause significant clinical symptoms or changes in heart rate, blood pressure, oxygen saturation, and body temperature. Laboratory analysis revealed only minimal changes, including an increase in serum bilirubin levels and a decrease in serum creatinine, chloride, and blood glucose within normal values, regardless of NMN dosage. Ophthalmologic examination and sleep quality score showed no differences before and after NMN administration.

Furthermore, our research showed that plasma concentrations of N-methyl-2-pyridone-5-carboxamide and N-methyl-4-pyridone-5-carboxamide significantly increased with increasing NMN dose. Overall, single oral administration of NMN was safe and effectively metabolized in healthy men without causing significant adverse effects.

Our findings support the feasibility of oral administration of NMN as a potential therapeutic strategy to reduce age-related conditions in humans. However, further research on the safety and effectiveness of NMN in long-term use is needed to draw definitive conclusions.

Source: https://pubmed.ncbi.nlm.nih.gov/31685720/

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